Microsatellite Instability Line

Test for micro satellite instability in colorectal cancers

In hereditary non-polyposis colorectal cancer (HNPCC) 85-90% of cases show microsatellite instability (MSI). MSI is characterized by a different number of short repeated DNA sequences between tumor and normal tissue.
The microsatellite instability status represents a prognostic and predictive factor for colorectal cancer: patients with high microsatellite instability (MSI-H) have a better prognosis than those with stable microsatellites (MSS) and some studies suggest that MSI-H tumors are less responsive to adjuvant chemotherapy with 5-fuorouracil.
Titano MSI kit allows the determination of microsatellite instability status in colorectal cancer samples by multiplex amplification with fluorescent primers and subsequent DNA fragment analysis on an automated sequencer.