Microsatellite Instability Line
Test for micro satellite instability in colorectal cancers
In hereditary non-polyposis colorectal cancer (HNPCC) 85-90% of
cases show microsatellite instability (MSI). MSI is characterized
by a different number of short repeated DNA sequences between
tumor and normal tissue.
The microsatellite instability status represents a prognostic and
predictive factor for colorectal cancer: patients with high
microsatellite instability (MSI-H) have a better prognosis than
those with stable microsatellites (MSS) and some studies suggest
that MSI-H tumors are less responsive to adjuvant chemotherapy
with 5-fuorouracil.
Titano MSI kit allows the determination of microsatellite
instability status in colorectal cancer samples by multiplex
amplification with fluorescent primers and subsequent DNA fragment
analysis on an automated sequencer.